Gastrostomy tube placement for long-term oral drug administration in non-human primates.
Identifieur interne : 000840 ( Main/Exploration ); précédent : 000839; suivant : 000841Gastrostomy tube placement for long-term oral drug administration in non-human primates.
Auteurs : Jong-Min Kim [Corée du Sud] ; Jun-Seop Shin [Corée du Sud] ; Byoung-Hoon Min [Corée du Sud] ; Jung-Sik Kim [Corée du Sud] ; Il-Hee Yoon [Corée du Sud] ; Won-Young Jeong [Corée du Sud] ; Ga-Eul Lee [Corée du Sud] ; Min-Sun Kim [Corée du Sud] ; Ju-Eun Kim [Corée du Sud] ; Chung-Gyu Park [Corée du Sud]Source :
- Xenotransplantation [ 1399-3089 ] ; 2017.
Descripteurs français
- KwdFr :
- Ablation de dispositif (MeSH), Administration par voie orale (MeSH), Animaux (MeSH), Complications postopératoires (MeSH), Femelle (MeSH), Gastrostomie (méthodes), Immunosuppresseurs (administration et posologie), Immunosuppresseurs (pharmacologie), Macaca mulatta (MeSH), Mâle (MeSH), Temps (MeSH), Transplantation hétérologue (méthodes).
- MESH :
- administration et posologie : Immunosuppresseurs.
- méthodes : Gastrostomie, Transplantation hétérologue.
- pharmacologie : Immunosuppresseurs.
- Ablation de dispositif, Administration par voie orale, Animaux, Complications postopératoires, Femelle, Macaca mulatta, Mâle, Temps.
English descriptors
- KwdEn :
- Administration, Oral (MeSH), Animals (MeSH), Device Removal (MeSH), Female (MeSH), Gastrostomy (methods), Immunosuppressive Agents (administration & dosage), Immunosuppressive Agents (pharmacology), Macaca mulatta (MeSH), Male (MeSH), Postoperative Complications (MeSH), Time (MeSH), Transplantation, Heterologous (methods).
- MESH :
- chemical , administration & dosage : Immunosuppressive Agents.
- methods : Gastrostomy, Transplantation, Heterologous.
- chemical , pharmacology : Immunosuppressive Agents.
- Administration, Oral, Animals, Device Removal, Female, Macaca mulatta, Male, Postoperative Complications, Time.
Abstract
BACKGROUND
Non-human primates (NHPs) are often used as recipients in preclinical transplantation research that in most cases involves administration of various drugs including immunosuppressants. Long-term oral drug administration, particularly tacrolimus, is challenging in the transplant recipient NHPs. Oral drug administration method using the mixture of drug and fruit juice has been used in NHPs, but this is not always effective in all monkeys. To those monkeys who are poorly compliant, oral drug administration in restraint or administration using gastrostomy tube should be necessary. The aim of this study was to compare the efficacy of between oral drug administration in restraint and administration using gastrostomy tube and to report complications and solutions to overcome the problems related to gastrostomy tube for long-term oral drug dosing in rhesus monkeys.
METHODS
Fifteen of 4- to 5-year-old male and female healthy rhesus monkeys weighing 5.0-6.8 kg were used as recipients for porcine pancreatic islet transplantation. Oral drug administration in restraint was used for four monkeys, and gastrostomy tube was placed to other 11 monkeys (8-French Feeding tube, n=6; Tri-Funnel Replacement Gastrostomy tube, n=5). Oral immunosuppressive drugs such as sirolimus and tacrolimus were administered through the tube. The efficacy and the extent of ease for administration and related complications were compared between two groups.
RESULTS AND CONCLUSIONS
The complication of gastrostomy included a transient inflammation in the skin and peritonitis caused by a leakage around implantation site (one case), which could be overcome by changing suture method and tube type to interlocking box suture and Tri-Funnel Replacement Gastrostomy tube, respectively. Despite these complications, oral drug administration using gastrostomy tube allowed us to perform accurate dosage of drug administration and to reduce the stress that both the monkey and the researcher may experience. Taken together, this study showed that gastrostomy tube placement is a better alternative to oral drug administration in restraint for long-term oral drug administration in rhesus monkeys who tend to refuse to eat the mixture of drug and fruit juice.
DOI: 10.1111/xen.12292
PubMed: 28258588
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Séoul</region></placeName></affiliation></author><author><name sortKey="Yoon, Il Hee" sort="Yoon, Il Hee" uniqKey="Yoon I" first="Il-Hee" last="Yoon">Il-Hee Yoon</name><affiliation wicri:level="3"><nlm:affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement 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Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Ga Eul" sort="Lee, Ga Eul" uniqKey="Lee G" first="Ga-Eul" last="Lee">Ga-Eul Lee</name><affiliation wicri:level="3"><nlm:affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Min Sun" sort="Kim, Min Sun" uniqKey="Kim M" first="Min-Sun" last="Kim">Min-Sun Kim</name><affiliation wicri:level="3"><nlm:affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Ju Eun" sort="Kim, Ju Eun" uniqKey="Kim J" first="Ju-Eun" last="Kim">Ju-Eun Kim</name><affiliation wicri:level="3"><nlm:affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Chung Gyu" sort="Park, Chung Gyu" uniqKey="Park C" first="Chung-Gyu" last="Park">Chung-Gyu Park</name><affiliation wicri:level="3"><nlm:affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institute of Endemic Diseases, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute of Endemic Diseases, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Biomedical Research Institute, Seoul National University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Cancer Research Institute, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Cancer Research Institute, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28258588</idno><idno type="pmid">28258588</idno><idno 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Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institute of Endemic Diseases, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute of Endemic Diseases, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Biomedical Research Institute, Seoul National University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Shin, Jun Seop" sort="Shin, Jun Seop" uniqKey="Shin J" first="Jun-Seop" last="Shin">Jun-Seop Shin</name><affiliation wicri:level="3"><nlm:affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institute of Endemic Diseases, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute of Endemic Diseases, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Biomedical Research Institute, Seoul National University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Cancer Research Institute, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Cancer Research Institute, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Min, Byoung Hoon" sort="Min, Byoung Hoon" uniqKey="Min B" first="Byoung-Hoon" last="Min">Byoung-Hoon Min</name><affiliation wicri:level="3"><nlm:affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Cancer Research Institute, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Cancer Research Institute, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Jung Sik" sort="Kim, Jung Sik" uniqKey="Kim J" first="Jung-Sik" last="Kim">Jung-Sik Kim</name><affiliation wicri:level="3"><nlm:affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institute of Endemic Diseases, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute of Endemic Diseases, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Biomedical Research Institute, Seoul National University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Cancer Research Institute, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Cancer Research Institute, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yoon, Il Hee" sort="Yoon, Il Hee" uniqKey="Yoon I" first="Il-Hee" last="Yoon">Il-Hee Yoon</name><affiliation wicri:level="3"><nlm:affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Cancer Research Institute, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Cancer Research Institute, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jeong, Won Young" sort="Jeong, Won Young" uniqKey="Jeong W" first="Won-Young" last="Jeong">Won-Young Jeong</name><affiliation wicri:level="3"><nlm:affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Ga Eul" sort="Lee, Ga Eul" uniqKey="Lee G" first="Ga-Eul" last="Lee">Ga-Eul Lee</name><affiliation wicri:level="3"><nlm:affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Min Sun" sort="Kim, Min Sun" uniqKey="Kim M" first="Min-Sun" last="Kim">Min-Sun Kim</name><affiliation wicri:level="3"><nlm:affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Ju Eun" sort="Kim, Ju Eun" uniqKey="Kim J" first="Ju-Eun" last="Kim">Ju-Eun Kim</name><affiliation wicri:level="3"><nlm:affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Chung Gyu" sort="Park, Chung Gyu" uniqKey="Park C" first="Chung-Gyu" last="Park">Chung-Gyu Park</name><affiliation wicri:level="3"><nlm:affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institute of Endemic Diseases, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute of Endemic Diseases, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Biomedical Research Institute, Seoul National University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Cancer Research Institute, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Cancer Research Institute, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, Seoul National University Graduate School, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Xenotransplantation</title><idno type="eISSN">1399-3089</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral (MeSH)</term><term>Animals (MeSH)</term><term>Device Removal (MeSH)</term><term>Female (MeSH)</term><term>Gastrostomy (methods)</term><term>Immunosuppressive Agents (administration & dosage)</term><term>Immunosuppressive Agents (pharmacology)</term><term>Macaca mulatta (MeSH)</term><term>Male (MeSH)</term><term>Postoperative Complications (MeSH)</term><term>Time (MeSH)</term><term>Transplantation, Heterologous (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Ablation de dispositif (MeSH)</term><term>Administration par voie orale (MeSH)</term><term>Animaux (MeSH)</term><term>Complications postopératoires (MeSH)</term><term>Femelle (MeSH)</term><term>Gastrostomie (méthodes)</term><term>Immunosuppresseurs (administration et posologie)</term><term>Immunosuppresseurs (pharmacologie)</term><term>Macaca mulatta (MeSH)</term><term>Mâle (MeSH)</term><term>Temps (MeSH)</term><term>Transplantation hétérologue (méthodes)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Immunosuppresseurs</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Gastrostomy</term><term>Transplantation, Heterologous</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Gastrostomie</term><term>Transplantation hétérologue</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Immunosuppresseurs</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Device Removal</term><term>Female</term><term>Macaca mulatta</term><term>Male</term><term>Postoperative Complications</term><term>Time</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Ablation de dispositif</term><term>Administration par voie orale</term><term>Animaux</term><term>Complications postopératoires</term><term>Femelle</term><term>Macaca mulatta</term><term>Mâle</term><term>Temps</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Non-human primates (NHPs) are often used as recipients in preclinical transplantation research that in most cases involves administration of various drugs including immunosuppressants. Long-term oral drug administration, particularly tacrolimus, is challenging in the transplant recipient NHPs. Oral drug administration method using the mixture of drug and fruit juice has been used in NHPs, but this is not always effective in all monkeys. To those monkeys who are poorly compliant, oral drug administration in restraint or administration using gastrostomy tube should be necessary. The aim of this study was to compare the efficacy of between oral drug administration in restraint and administration using gastrostomy tube and to report complications and solutions to overcome the problems related to gastrostomy tube for long-term oral drug dosing in rhesus monkeys.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Fifteen of 4- to 5-year-old male and female healthy rhesus monkeys weighing 5.0-6.8 kg were used as recipients for porcine pancreatic islet transplantation. Oral drug administration in restraint was used for four monkeys, and gastrostomy tube was placed to other 11 monkeys (8-French Feeding tube, n=6; Tri-Funnel Replacement Gastrostomy tube, n=5). Oral immunosuppressive drugs such as sirolimus and tacrolimus were administered through the tube. The efficacy and the extent of ease for administration and related complications were compared between two groups.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS AND CONCLUSIONS</b></p><p>The complication of gastrostomy included a transient inflammation in the skin and peritonitis caused by a leakage around implantation site (one case), which could be overcome by changing suture method and tube type to interlocking box suture and Tri-Funnel Replacement Gastrostomy tube, respectively. Despite these complications, oral drug administration using gastrostomy tube allowed us to perform accurate dosage of drug administration and to reduce the stress that both the monkey and the researcher may experience. Taken together, this study showed that gastrostomy tube placement is a better alternative to oral drug administration in restraint for long-term oral drug administration in rhesus monkeys who tend to refuse to eat the mixture of drug and fruit juice.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28258588</PMID><DateCompleted><Year>2017</Year><Month>11</Month><Day>09</Day></DateCompleted><DateRevised><Year>2017</Year><Month>12</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1399-3089</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>2</Issue><PubDate><Year>2017</Year><Month>03</Month></PubDate></JournalIssue><Title>Xenotransplantation</Title><ISOAbbreviation>Xenotransplantation</ISOAbbreviation></Journal><ArticleTitle>Gastrostomy tube placement for long-term oral drug administration in non-human primates.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1111/xen.12292</ELocationID><Abstract><AbstractText Label="BACKGROUND">Non-human primates (NHPs) are often used as recipients in preclinical transplantation research that in most cases involves administration of various drugs including immunosuppressants. Long-term oral drug administration, particularly tacrolimus, is challenging in the transplant recipient NHPs. Oral drug administration method using the mixture of drug and fruit juice has been used in NHPs, but this is not always effective in all monkeys. To those monkeys who are poorly compliant, oral drug administration in restraint or administration using gastrostomy tube should be necessary. The aim of this study was to compare the efficacy of between oral drug administration in restraint and administration using gastrostomy tube and to report complications and solutions to overcome the problems related to gastrostomy tube for long-term oral drug dosing in rhesus monkeys.</AbstractText><AbstractText Label="METHODS">Fifteen of 4- to 5-year-old male and female healthy rhesus monkeys weighing 5.0-6.8 kg were used as recipients for porcine pancreatic islet transplantation. Oral drug administration in restraint was used for four monkeys, and gastrostomy tube was placed to other 11 monkeys (8-French Feeding tube, n=6; Tri-Funnel Replacement Gastrostomy tube, n=5). Oral immunosuppressive drugs such as sirolimus and tacrolimus were administered through the tube. The efficacy and the extent of ease for administration and related complications were compared between two groups.</AbstractText><AbstractText Label="RESULTS AND CONCLUSIONS">The complication of gastrostomy included a transient inflammation in the skin and peritonitis caused by a leakage around implantation site (one case), which could be overcome by changing suture method and tube type to interlocking box suture and Tri-Funnel Replacement Gastrostomy tube, respectively. Despite these complications, oral drug administration using gastrostomy tube allowed us to perform accurate dosage of drug administration and to reduce the stress that both the monkey and the researcher may experience. Taken together, this study showed that gastrostomy tube placement is a better alternative to oral drug administration in restraint for long-term oral drug administration in rhesus monkeys who tend to refuse to eat the mixture of drug and fruit juice.</AbstractText><CopyrightInformation>© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Jong-Min</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Endemic Diseases, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shin</LastName><ForeName>Jun-Seop</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Endemic Diseases, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cancer Research Institute, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Min</LastName><ForeName>Byoung-Hoon</ForeName><Initials>BH</Initials><AffiliationInfo><Affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cancer Research Institute, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Jung-Sik</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Endemic Diseases, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cancer Research Institute, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yoon</LastName><ForeName>Il-Hee</ForeName><Initials>IH</Initials><AffiliationInfo><Affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cancer Research Institute, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeong</LastName><ForeName>Won-Young</ForeName><Initials>WY</Initials><AffiliationInfo><Affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Ga-Eul</ForeName><Initials>GE</Initials><AffiliationInfo><Affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Min-Sun</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Ju-Eun</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Chung-Gyu</ForeName><Initials>CG</Initials><Identifier Source="ORCID">0000-0003-4083-8791</Identifier><AffiliationInfo><Affiliation>Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Endemic Diseases, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cancer Research Institute, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>03</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>Denmark</Country><MedlineTA>Xenotransplantation</MedlineTA><NlmUniqueID>9438793</NlmUniqueID><ISSNLinking>0908-665X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000284" MajorTopicYN="N">Administration, Oral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020878" MajorTopicYN="N">Device Removal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005774" MajorTopicYN="Y">Gastrostomy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007166" MajorTopicYN="N">Immunosuppressive Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008253" MajorTopicYN="N">Macaca mulatta</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011183" MajorTopicYN="N">Postoperative Complications</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013995" MajorTopicYN="N">Time</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014183" MajorTopicYN="N">Transplantation, Heterologous</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">gastrostomy tube</Keyword><Keyword MajorTopicYN="Y">oral drug administration</Keyword><Keyword MajorTopicYN="Y">restrain</Keyword><Keyword MajorTopicYN="Y">rhesus monkey</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>09</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>01</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>01</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>3</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>11</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>3</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28258588</ArticleId><ArticleId IdType="doi">10.1111/xen.12292</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kim, Jong Min" sort="Kim, Jong Min" uniqKey="Kim J" first="Jong-Min" last="Kim">Jong-Min Kim</name></region><name sortKey="Jeong, Won Young" sort="Jeong, Won Young" uniqKey="Jeong W" first="Won-Young" last="Jeong">Won-Young Jeong</name><name sortKey="Kim, Jong Min" sort="Kim, Jong Min" uniqKey="Kim J" first="Jong-Min" last="Kim">Jong-Min Kim</name><name sortKey="Kim, Jong Min" sort="Kim, Jong Min" uniqKey="Kim J" first="Jong-Min" last="Kim">Jong-Min Kim</name><name sortKey="Kim, Ju Eun" sort="Kim, Ju Eun" uniqKey="Kim J" first="Ju-Eun" last="Kim">Ju-Eun Kim</name><name sortKey="Kim, Jung Sik" sort="Kim, Jung Sik" uniqKey="Kim J" first="Jung-Sik" last="Kim">Jung-Sik Kim</name><name sortKey="Kim, Jung Sik" sort="Kim, Jung Sik" uniqKey="Kim J" first="Jung-Sik" last="Kim">Jung-Sik Kim</name><name sortKey="Kim, Jung Sik" sort="Kim, Jung Sik" uniqKey="Kim J" first="Jung-Sik" last="Kim">Jung-Sik Kim</name><name sortKey="Kim, Jung Sik" sort="Kim, Jung Sik" uniqKey="Kim J" first="Jung-Sik" last="Kim">Jung-Sik Kim</name><name sortKey="Kim, Jung Sik" sort="Kim, Jung Sik" uniqKey="Kim J" first="Jung-Sik" last="Kim">Jung-Sik Kim</name><name sortKey="Kim, Min Sun" sort="Kim, Min Sun" uniqKey="Kim M" first="Min-Sun" last="Kim">Min-Sun Kim</name><name sortKey="Lee, Ga Eul" sort="Lee, Ga Eul" uniqKey="Lee G" first="Ga-Eul" last="Lee">Ga-Eul Lee</name><name sortKey="Min, Byoung Hoon" sort="Min, Byoung Hoon" uniqKey="Min B" first="Byoung-Hoon" last="Min">Byoung-Hoon Min</name><name sortKey="Min, Byoung Hoon" sort="Min, Byoung Hoon" uniqKey="Min B" first="Byoung-Hoon" last="Min">Byoung-Hoon Min</name><name sortKey="Min, Byoung Hoon" sort="Min, Byoung Hoon" uniqKey="Min B" first="Byoung-Hoon" last="Min">Byoung-Hoon Min</name><name sortKey="Park, Chung Gyu" sort="Park, Chung Gyu" uniqKey="Park C" first="Chung-Gyu" last="Park">Chung-Gyu Park</name><name sortKey="Park, Chung Gyu" sort="Park, Chung Gyu" uniqKey="Park C" first="Chung-Gyu" last="Park">Chung-Gyu Park</name><name sortKey="Park, Chung Gyu" sort="Park, Chung Gyu" uniqKey="Park C" first="Chung-Gyu" last="Park">Chung-Gyu Park</name><name sortKey="Park, Chung Gyu" sort="Park, Chung Gyu" uniqKey="Park C" first="Chung-Gyu" last="Park">Chung-Gyu Park</name><name sortKey="Park, Chung Gyu" sort="Park, Chung Gyu" uniqKey="Park C" first="Chung-Gyu" last="Park">Chung-Gyu Park</name><name sortKey="Park, Chung Gyu" sort="Park, Chung Gyu" uniqKey="Park C" first="Chung-Gyu" last="Park">Chung-Gyu Park</name><name sortKey="Shin, Jun Seop" sort="Shin, Jun Seop" uniqKey="Shin J" first="Jun-Seop" last="Shin">Jun-Seop Shin</name><name sortKey="Shin, Jun Seop" sort="Shin, Jun Seop" uniqKey="Shin J" first="Jun-Seop" last="Shin">Jun-Seop Shin</name><name sortKey="Shin, Jun Seop" sort="Shin, Jun Seop" uniqKey="Shin J" first="Jun-Seop" last="Shin">Jun-Seop Shin</name><name sortKey="Shin, Jun Seop" sort="Shin, Jun Seop" uniqKey="Shin J" first="Jun-Seop" last="Shin">Jun-Seop Shin</name><name sortKey="Shin, Jun Seop" sort="Shin, Jun Seop" uniqKey="Shin J" first="Jun-Seop" last="Shin">Jun-Seop Shin</name><name sortKey="Yoon, Il Hee" sort="Yoon, Il Hee" uniqKey="Yoon I" first="Il-Hee" last="Yoon">Il-Hee Yoon</name><name sortKey="Yoon, Il Hee" sort="Yoon, Il Hee" uniqKey="Yoon I" first="Il-Hee" last="Yoon">Il-Hee Yoon</name><name sortKey="Yoon, Il Hee" sort="Yoon, Il Hee" uniqKey="Yoon I" first="Il-Hee" last="Yoon">Il-Hee 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